YouTubers & Twitch streamers who play The Binding of Isaac
Last updated: October 12, 2026
The Binding of Isaac is the twin-stick roguelike that pioneered item-synergy depth and remains a genre benchmark. The creators below actively cover it, which makes them strong targets if your indie game shares that audience. Use the list to shortlist micro-influencers, then manage outreach in CreatorScout.
The Binding of Isaac remains a benchmark for twin-stick roguelike fans and deep item-synergy theorycrafters. Its enormous pool of combinable items produces run-defining power spikes and surprises, giving long-running creators endless variety and a challenge ceiling that keeps mastery-focused streams and daily-run content perpetually engaging.
- Sinvicta
Erase EVERYTHING! - The Binding Of Isaac #656
336K
Subscribers
- Another Matt Playing Isaac
Beginner's Guide to the Binding of Isaac
109K
Subscribers
- Nick AR
The Binding of Isaac's Platinum is ADDICTING
469K
Subscribers
- CarlPlayin42
The Binding of Isaac Completely Unspoiled First Playthrough // LOVE THIS GAME [Ep. 1]
32.1K
Subscribers
- Quiet Igloo
The Binding of Isaac: Rebirth | Gameplay | No Commentary
780
Subscribers
- Lonslo
Every Item is The Black Box (it's broken)
113K
Subscribers
- Cooked Elk
How To Break As Isaac *EASY EDITION*
53.7K
Subscribers
- WompGG
How to PISS OFF a Binding Of Isaac Player
4K
Subscribers
- AnxiGames
This One Pill Is All You Need
755
Subscribers
- Kayhos
That's Why I Don't Play Coop... #thebindingofisaac #kayhosyt
348K
Subscribers
- 🜏El Mapache of Isaac🜏
WOULD You GUESS The REAL One!? // Tboi Repentance
29.2K
Subscribers
- Jaj
Isaac... Can JEVIL do EVERYTHING?
6K
Subscribers
Data from YouTube
Frequently asked questions
How do I find YouTubers who played The Binding of Isaac?
Search “The Binding of Isaac” in CreatorScout to pull a live list of YouTube and Twitch creators who have recently covered it. Filter by subscriber range, language, and recency to narrow down to micro-influencers whose audience already matches what your game offers.
Should I target big or small The Binding of Isaac creators?
For most indie game launches, micro-influencers (roughly 1k–100k subscribers) who regularly cover The Binding of Isaac outperform larger generalist channels. Smaller creators have higher engagement rates, more responsive audiences, and are more likely to reply to a cold pitch. Fit with your game's genre matters more than raw subscriber count.
How many Steam keys should I send to influencers?
Start with a focused list of well-matched creators and send keys only to those who respond positively to your pitch. Reserve a buffer for co-op coverage or follow-up requests. Sending keys broadly without personalised outreach rarely pays off. A smaller, more targeted batch almost always converts better.
Related guides
Browse by genre
Pitching a game like The Binding of Isaac?
Search any competitor title, filter by audience size and platform, and track your Steam-key outreach end-to-end.
Find creators for your game