YouTubers & Twitch streamers who play The Binding of Isaac
Last updated: June 22, 2026
The Binding of Isaac is the twin-stick roguelike that pioneered item-synergy depth and remains a genre benchmark. The creators below actively cover it, which makes them strong targets if your indie game shares that audience. Use the list to shortlist micro-influencers, then manage outreach in CreatorScout.
The Binding of Isaac remains a benchmark for twin-stick roguelike fans and deep item-synergy theorycrafters. Its enormous pool of combinable items produces run-defining power spikes and surprises, giving long-running creators endless variety and a challenge ceiling that keeps mastery-focused streams and daily-run content perpetually engaging.
- Sinvicta
What a combo! - The Binding Of Isaac Repentance+ #581
336K
Subscribers
- Markiplier
WHAT IS THAT!? | Binding of Isaac - Part 1
38.7M
Subscribers
- Quiet Igloo
The Binding of Isaac: Rebirth | Gameplay | No Commentary
747
Subscribers
- Lazy Mattman
The Most Satisfying Isaac Run
587K
Subscribers
- ZackLillipad
The Binding of Isaac RUINED Video Games For Me...
29.9K
Subscribers
- Kayhos
TIPS FOR BEGINNERS OF BINDING OF ISAAC
327K
Subscribers
- ZackScottGames
The Binding of Isaac: Rebirth - Gameplay Walkthrough Part 1 - Isaac First Run (PC)
5.5M
Subscribers
Nuna_NunchiFinally playing Dark Souls >_O
0
Est. followers
Casperion_TVBinding Of Isaac Today | Let's Learn How To Play The Game Together | Ori Playthrough Later
0
Est. followers
OhdissIssac First TIme! →Meccha
0
Est. followers
ZiggySma11zWaiting for online console Co-op
0
Est. followers
krogers1987ISAAC GRIND TO DEAD GOD
0
Est. followers
Frequently asked questions
How do I find YouTubers who played The Binding of Isaac?
Search “The Binding of Isaac” in CreatorScout to pull a live list of YouTube and Twitch creators who have recently covered it. Filter by subscriber range, language, and recency to narrow down to micro-influencers whose audience already matches what your game offers.
Should I target big or small The Binding of Isaac creators?
For most indie game launches, micro-influencers (roughly 1k–100k subscribers) who regularly cover The Binding of Isaac outperform larger generalist channels. Smaller creators have higher engagement rates, more responsive audiences, and are more likely to reply to a cold pitch. Fit with your game's genre matters more than raw subscriber count.
How many Steam keys should I send to influencers?
Start with a focused list of well-matched creators and send keys only to those who respond positively to your pitch. Reserve a buffer for co-op coverage or follow-up requests. Sending keys broadly without personalised outreach rarely pays off. A smaller, more targeted batch almost always converts better.
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